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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL1
All Species:
4.55
Human Site:
T307
Identified Species:
7.69
UniProt:
Q00532
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00532
NP_004187.2
357
41671
T307
H
N
K
P
T
R
K
T
L
R
K
S
R
K
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100233
358
41783
T308
H
D
K
P
T
R
K
T
L
R
K
S
R
K
H
Dog
Lupus familis
XP_851358
367
42581
P317
R
Q
S
R
K
H
L
P
G
V
K
V
G
H
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8CEQ0
352
41005
K302
E
L
T
R
Q
H
D
K
P
A
R
K
T
L
R
Rat
Rattus norvegicus
Q66HE7
352
40881
K302
E
L
A
R
P
H
D
K
P
T
R
K
T
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
R302
D
L
A
R
E
Q
E
R
P
S
R
R
P
P
R
Chicken
Gallus gallus
P13863
303
34670
Q254
G
S
L
G
T
H
V
Q
N
L
D
E
D
G
L
Frog
Xenopus laevis
P35567
302
34487
V253
G
G
S
L
S
A
N
V
K
N
I
D
K
D
G
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
E300
E
S
E
S
V
T
R
E
L
D
R
K
K
R
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
A434
Q
Q
F
M
L
A
T
A
A
Q
Q
L
Q
T
G
Honey Bee
Apis mellifera
XP_394980
385
44993
K329
A
E
M
E
E
F
E
K
L
K
K
N
R
D
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
R309
S
T
N
V
R
R
H
R
S
K
L
G
L
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
Q245
K
T
A
F
P
R
W
Q
A
Q
D
L
A
T
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
K245
K
S
A
F
P
K
W
K
P
T
D
L
E
T
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.7
88.5
N.A.
88.8
88.2
N.A.
86.5
37.8
36.9
77
N.A.
43.1
53.2
N.A.
59.5
Protein Similarity:
100
N.A.
99.1
92.6
N.A.
92.7
93
N.A.
92.7
52.3
54.6
87.9
N.A.
54.6
69.6
N.A.
73
P-Site Identity:
100
N.A.
93.3
6.6
N.A.
0
0
N.A.
0
6.6
0
6.6
N.A.
0
20
N.A.
6.6
P-Site Similarity:
100
N.A.
100
6.6
N.A.
6.6
6.6
N.A.
20
13.3
13.3
46.6
N.A.
20
40
N.A.
20
Percent
Protein Identity:
N.A.
34.4
N.A.
33
N.A.
N.A.
Protein Similarity:
N.A.
54.3
N.A.
54.6
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
29
0
0
15
0
8
15
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
8
0
0
0
0
15
0
0
8
22
8
8
15
0
% D
% Glu:
22
8
8
8
15
0
15
8
0
0
0
8
8
0
0
% E
% Phe:
0
0
8
15
0
8
0
0
0
0
0
0
0
0
8
% F
% Gly:
15
8
0
8
0
0
0
0
8
0
0
8
8
8
15
% G
% His:
15
0
0
0
0
29
8
0
0
0
0
0
0
8
15
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
15
0
15
0
8
8
15
29
8
15
29
22
15
15
8
% K
% Leu:
0
22
8
8
8
0
8
0
29
8
8
22
8
15
8
% L
% Met:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
0
8
0
8
8
0
8
0
0
0
% N
% Pro:
0
0
0
15
22
0
0
8
29
0
0
0
8
8
0
% P
% Gln:
8
15
0
0
8
8
0
15
0
15
8
0
8
0
0
% Q
% Arg:
8
0
0
29
8
29
8
15
0
15
29
8
22
15
29
% R
% Ser:
8
22
15
8
8
0
0
0
8
8
0
15
0
0
0
% S
% Thr:
0
15
8
0
22
8
8
15
0
15
0
0
15
22
8
% T
% Val:
0
0
0
8
8
0
8
8
0
8
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _